INVESTIGATIONS ON THE POTENTIALS OF NOVEL TECHNOLOGIES FOR AIRCRAFT FUEL BURN REDUCTION THROUGH AEROSTRUCTURAL OPTIMISATION

Investigations on the Potentials of Novel Technologies for Aircraft Fuel Burn Reduction through Aerostructural Optimisation

A physics-based optimisation framework is developed to investigate the potential advantages of novel technologies on the energy efficiency of a midrange passenger aircraft.In particular, the coupled-adjoint aerostructural analysis and optimisation tool FEMWET is modified to study the effects of active flow control at different load cases for conven

read more



Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21

Cytokines from the common gamma chain receptor family, such as IL-15, IL-21 and IL-7, show promise for cancer immunotherapy and have been incorporated individually into the immunocytokine approach.However, their efficacy as monotherapy is limited.Here, we investigated the molecular design of tumor-directed trifunctional antibody-cytokine fusion pro

read more